Protein Details: Neuronal acetylcholine receptor subunit beta-2

Protein ID

ICDB_Pro_0385

Protein Name

Neuronal acetylcholine receptor subunit beta-2

Gene Name

chrnb2

Organism

Carassius auratus (Goldfish)

Length

459 amino acids

AlphaFoldDB

AF-P19370-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

LRSDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISVNEREQIMTTNVWLTQEWTDYRLVWDPNEYEGIKKLRIPSQHIWLPDIVLYNNADGVYEVSFYCNAVVSNTGDIFWLPPAIYKSACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLVLTSDFASRDDYTPSGEWDIVSLPGRKNEDPNDLTYLDITYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKVTLCMSVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHYMPEWVKCVFLHKLPAFLLMRRPGRSNVRERFRRKHQRKSFSSHQDGDSFFLTDDPGRVCGAWRVGDLPEGSEFRQRVKVRHDQDVDEAIDGVRFIAEHMKIEDDDEGIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFVQPLFQSYNTPVAEEVYGDF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1083/jcb.108.2.637